A REVIEW OF PALMITOYLETHANOLAMIDE

Of Notice is that, resulting from PEA’s substantial lipophilicity, micronized or ultra-micronized formulations are thought to get more effortlessly absorbable, with much more favorable pharmacokinetics and greater efficacy. Whilst there is some evidence supporting this concept, there continues to be no proof from the superiority of micronized PEA

Central administration of palmitoylethanolamide reduces hyperalgesia in mice by means of inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolA medical example of hyperalgesia might be an amputee who is struggling to use a prosthesis due to tenderness overlying the stump.Information from balanced volunteers has also show